Best Home Run Prop Bets Today – HR Prop Picks For Monday, September 22

The 2025 MLB season is here, and who doesn’t love home run prop bets? Tons of home runs have already been hit this season and we’re ready to pick more winners in 2025! Free home run prop picks each day come at you compliments of WagerTalk.

Let’s see if we can beat the books with home run prop bets on Monday! You can find free MLB picks every day at WagerTalk! Here are the best home run prop bets to make for Monday, September 22!

Best Home Run Prop Bets – MLB Free HR Props Picks

Marcell Ozuna (ATL) +560

It has certainly been a down year for Marcell Ozuna to say the least with his 20 home runs the least amount he’s had in a regular season while playing at least 130 games in his career.

He sits just five home runs away from 300 as we’ll take him to hit his home run prop tonight at home with the Braves hosting the Nationals.

Lefty MacKenzie Gore takes the mound for Washington and although he hasn’t allowed a home run in his last three starts, Ozuna is 7-17 with a home run against him all-time.

The Braves return home after a short road trip and while playing at home Ozuna bats .243 while slugging .420 this season compared to road games batting .215 and slugging .376.

He has also loved playing Washington in general this season batting .361 and slugging .611 against them. Although the Braves don’t have anything to play for at this point in the season, spirits are currently high with the team riding eight straight wins.

Take Ozuna to hit a home run tonight at +560 odds. Other Braves batters to consider for a home run prop includes Ronald Acuna Jr. (+400) and Jurickson Profar (+560).

MLB HR Props Best Bet of the Day #2: Rafael Devers (SF) +390

Cardinals starter Michael McGreevy last allowed a home run during his start against the Giants at home as these two go head-to-head once more this season in San Francisco this time tonight.

Rafael Devers hit his home run prop in that game and we’re going to take him to do it again tonight with Devers batting .455 and slugging .818 against the Cardinals this season.

McGreevy has certainly preferred facing righties on the season allowing a .308 batting average and .494 slugging percentage to lefties compared to a .226 average and .322 slugging percentage against righties this season.

Some may call the Devers trade to the Giants a bust due to the team not making the playoffs but Devers has already topped 100 RBIs and hit 32 home runs with 17 of those coming with the Giants in 84 games.

He’s batting .256 and slugging .493 against righties this season so let’s take Devers to hit his home run prop tonight at +390 with other Giants batters to consider for a home run includes Willy Adames (+480) and Matt Chapman (+540).

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