Best MLB Home Run Props Today: HR Picks & Bets for September 22, 2026

Searching for the best home run props picks and predictions today? Plenty of home runs have already been hit this regular season, and we’re ready to find more winners on Tuesday! WagerTalk has you covered with free home run prop picks.

See if we can take down the sportsbooks with today’s home run prop bets, along with free MLB picks available every day at WagerTalk! Here are the top home run prop bets to consider for Tuesday, September 22!

Best MLB Home Run Props Today – Free HR Prop Picks & Bets

MLB Home Run Props Best Bet of the Day #1: Ronald Acuna Jr. (ATL) +350

We cashed with Ronald Acuna Jr. with home run props last Tuesday and we’re going back to him tonight as the Braves host the Reds in Atlanta tonight.

He’s been red hot this month batting .342 and slugging .699 including seven home runs and three of those coming across his last five games.

Acuna Jr. has absolutely loved playing Cincinnati this season going 5-10 with four of those hits coming as home runs with the Reds sending lefty Brandon Williamson to the mound. In limited work this season, Williamson hasn’t been bad on the road allowing three home runs in 24.2 innings pitched, but he has allowed one home run in four straight appearances (15.2 IP).

Sure, Acuna Jr. has been better against right handed pitching this season, but the Reds overall have allowed the third most home runs among all teams since the all-star break.

Their bullpen unit has allowed the sixth most home runs among all bullpen units this season so let’s take Acuna Jr. to hit his home run props tonight at +350 with other Braves to consider for home runs props being Matt Olson (+330) and Austin Riley (+420).

MLB Home Run Props Best Bet of the Day #2: Nolan Arenado (ARI) +420

Longtime former Rockies third baseman Nolan Arenado returns to Coors Field once again tonight as the Diamondbacks and Rockies start up a three-game series.

Arenado has certainly turned back the clock this season blasting 27 home runs thus far which is his highest total since he had 30 back in 2022 with the Cardinals.

We’ll look for him to cash his home run props tonight hitting .317 and slugging .650 for the Diamondbacks in September including six home runs.

Lefty Kyle Freeland gets the start for Colorado having allowed 27 home runs in total this season including five across his last two starts (7.2 IP).

Both of those starts came at home against fellow NL West rivals (Padres and Dodgers) with Arenado going 5-10 with two doubles all-time against Freeland.

Against lefties in general this season Arenado is batting .265 and slugging .544 compared to righties batting .241 and slugging .422. Most recently, Arenado hit a go-ahead grand slam for the Rockies in their 8-4 win over the Yankees on Sunday as the Diamondbacks have to win as much as they can in this final week to keep their slim playoff hopes alive.

In a hitter friendly environment, let’s take Arenado and his hot bat at +420 to hit his home run props tonight. Other Diamondbacks to consider for home run props includes Ketel Marte (+235) and Corbin Carroll (+390).

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