Rams vs Raiders Predictions, Picks and Odds For October 25, 2026

Five weeks ago, Las Vegas looked like a team in control. Now the Raiders sit at 3-3 after three straight losses, yet they are still 5-1 against the spread and coming off a back-and-forth battle with Buffalo that proved they can hang with anyone.

Meanwhile, the Rams limp in after a loss to Arizona that cost them Davante Adams, two starting defensive tackles and another placekicker. Los Angeles has won the last four meetings in this regional matchup, but the betting market has already chopped this spread in half.

Our Rams vs Raiders prediction breaks down the line movement, the injury fallout and why the home underdog is poised to strike. For more NFL predictions, check out our full slate before kickoff.

Rams vs Raiders Quick Picks and Prediction

Moneyline Pick: Las Vegas moneyline
Spread Pick: Las Vegas +3.5 (-105)
Total Pick: Over 48.5 (-108)
Projected Final Score: Raiders 27, Rams 24

Odds and Line Movement for Rams vs Raiders

Los Angeles opened as a 7-point road favorite, but the line has collapsed all the way to -3.5. The total has climbed from 47.5 to 48.5. Keep an eye on every move with our live odds page leading up to kickoff.

Opening Odds

Team	Spread	Total
Los Angeles	-7 (-105)	Over 47.5 (-110)
Las Vegas	+7 (-115)	Under 47.5 (-110)

Current Odds

Team	Spread	Total
Los Angeles	-3.5 (-115)	Over 48.5 (-108)
Las Vegas	+3.5 (-105)	Under 48.5 (-112)

Line Movement – Spread

Date	Los Angeles	Las Vegas
10/22	-3.5 (-115)	+3.5 (-105)
10/19	-4.5 (-105)	+4.5 (-115)
10/19	-4.5 (-110)	+4.5 (-110)
10/19	-4.5 (-115)	+4.5 (-105)
10/18	-5.5 (-110)	+5.5 (-110)
10/18	-6 (-110)	+6 (-110)
10/13	-7 (-105)	+7 (-115)

This spread has fallen three and a half points since opening, dropping through 6, 5.5 and 4.5 before landing at 3.5. Early money backed Los Angeles, but the action flipped hard after the Rams’ injury news. Las Vegas now holds 83 percent of the money and 66 percent of the tickets.

Line Movement – Total

Date	Over	Under
10/20	48.5 (-108)	48.5 (-112)
10/20	47.5 (-115)	47.5 (-105)
10/19	47.5 (-110)	47.5 (-110)
10/19	47.5 (-108)	47.5 (-112)
10/19	47.5 (-102)	47.5 (-118)
10/19	46.5 (-120)	46.5 (+100)
10/19	47.5 (-102)	47.5 (-118)
10/18	46.5 (-118)	46.5 (-102)
10/18	46.5 (-115)	46.5 (-105)
10/18	47.5 (-105)	47.5 (-115)
10/18	46.5 (-118)	46.5 (-102)
10/18	47.5 (-105)	47.5 (-115)
10/18	47.5 (-110)	47.5 (-110)

The total bounced between 46.5 and 47.5 through the weekend while early money leaned under. That changed on 10/20, when the number jumped to 48.5 with the over drawing 88 percent of the money and 86 percent of the tickets.

Rams vs Raiders Key Matchups and Handicap

Los Angeles Owns the Recent Series

The Rams have won each of the last four meetings in this regional matchup, most recently a 20-15 home win in October 2024. Each of the last three meetings has also stayed under the total. That history matters, but the version of Los Angeles that takes the field this week is far more banged up than the teams that built that streak.

Los Angeles Hit Hard by Injuries

Last week’s loss to Arizona was costly for the Rams. WR Davante Adams suffered a ruptured hamstring and will likely miss the next six weeks. Defensive tackles Poona Ford and Kobie Turner have both been placed on IR, and Myles Garrett has not been cleared to return. Losing that much talent on both sides of the ball is a big reason this spread has dropped so dramatically.

Rams Kicking Carousel Continues

The Rams’ placekicker saga has taken a strange turn over the past two weeks. One week after cutting Harrison Mevis, Los Angeles was forced to put Blake Grupe on IR with a knee injury suffered against the Cardinals. In a game that could come down to the final possessions, uncertainty at kicker is a real concern for anyone laying points with the Rams.

Raiders Battle-Tested After Buffalo

The Raiders have dropped three straight to fall to 3-3, but Las Vegas is still 5-1 against the spread this season. Kirk Cousins and company were feisty last week against Buffalo, trading blows with the Bills before falling behind in the fourth quarter.

That game featured 27 points in the final quarter alone, and the Raiders’ last four games have all gone over the total. Las Vegas should come in playing with confidence and ready to compete for 60 minutes.

Las Vegas Defense Outperformed LA Against the Bills

Both teams faced Buffalo over the last two weeks, which offers a useful comparison. The Raiders’ defense held the Bills to 345 total yards and 23 first downs on 5.4 yards per play. The Rams allowed 436 total yards and 25 first downs on 7.6 yards per play.

Los Angeles also arguably caught Buffalo in a better spot, as the Bills were flying across the country after a division game against New England with Josh Allen battling a couple of nagging injuries. The Rams’ recent performances are not aging well, and the visitors would likely need a two-touchdown lead in the fourth quarter to feel comfortable.

LAR vs LV Betting Trends

Los Angeles has won each of the last four meetings with Las Vegas.
The last three Los Angeles vs Las Vegas meetings have stayed under the total.
Las Vegas is 5-1 against the spread this season despite a 3-3 record.
Las Vegas’ last four games have all gone over the total.
Las Vegas’ game against Buffalo last week featured 27 fourth-quarter points.
The spread has dropped from Los Angeles -7 to -3.5, with Las Vegas holding 83 percent of the money and 66 percent of the tickets.
The total has risen from 47.5 to 48.5, with 88 percent of the money and 86 percent of the tickets on the over.

LAR vs LV Key Injuries and Notes

Rams WR Davante Adams (ruptured hamstring) will likely miss the next six weeks.
Rams DTs Poona Ford and Kobie Turner have been placed on IR.
Rams pass rusher Myles Garrett has not been cleared to return.
Rams K Blake Grupe (knee) was placed on IR one week after the team cut Harrison Mevis.
Las Vegas held Buffalo to 5.4 yards per play, while Los Angeles allowed 7.6 yards per play to the Bills.
Check final injury reports and the Rams’ kicking situation before kickoff, as both could affect this line.

ATS and Total Picks

Raiders +3.5 Spread Pick

Las Vegas has been one of the most reliable teams against the spread this season, and the matchup sets up well for the Raiders. Los Angeles is missing its top receiver, two starting defensive tackles and its kicker, while Las Vegas just proved it can compete with Buffalo for four quarters. The Raiders also handled the Bills better defensively than the Rams did. The market has moved three and a half points toward Las Vegas, and the Raiders have every reason to believe they can win this game outright.

Pick: Las Vegas +3.5 (-105)

LV vs LAR Over Pick

The series history leans under, but current form points the other way. Las Vegas has gone over in four straight games, including a wild fourth quarter against Buffalo.

The Rams’ defense is missing key pieces up front and gave up 7.6 yards per play to the Bills before those injuries piled up. The total has climbed to 48.5 with nearly all of the action on the over, and the matchup supports another high-scoring game.

Pick: Over 48.5 (-108)

Rams vs Raiders Best Bets

Best Bet: Las Vegas +3.5 (-105)
Moneyline: Las Vegas to win outright
Total: Over 48.5 (-108)

The top play is Las Vegas with the hook. The Raiders are 5-1 against the spread, they are coming off a confidence-building effort against Buffalo, and they face a Rams team decimated by injuries. Bettors who believe the upset is coming can back Las Vegas on the moneyline, while the Raiders’ four-game over streak and the Rams’ depleted defense make the over a strong complement.

Final Score Prediction for Rams vs Raiders

Las Vegas matches Los Angeles score for score, and the Rams’ defensive injuries show up in the fourth quarter once again. Cousins leads a late drive, the Rams’ kicking uncertainty costs them points, and the Raiders snap their three-game losing streak with an upset win at home.