Cardinals vs Rams Prediction, Picks and Odds

The Arizona Cardinals have lost four straight games by an average of 16.5 points and are allowing 37 points per game during the skid. Now they face a Rams team that racked up 454 yards and 33 first downs last week and still lost, thanks to two missed field goals and 11 penalties.

Sean McVay’s group should arrive angry, and Arizona’s pass defense ranks 31st in EPA per drop-back allowed. Both teams have seen their last three games go over the total, and the Rams have won five of the last six meetings.

Our Cardinals vs Rams prediction breaks down why this NFC West clash could turn into a lopsided shootout, how the spread climbed two full points and where the value sits on the spread, moneyline and total. For more free NFL predictions, check out the rest of our weekly card.

Cardinals vs Rams Quick Picks and Prediction

Spread Pick: Los Angeles Rams -12.5 (-115)
Total Pick: Over 51.5 (-115)
Projected Final Score: Rams 38, Cardinals 20

Odds and Line Movement for Cardinals vs Rams

The Rams opened as 10.5-point favorites and jumped to -12.5 on 10/11, briefly reaching -13.5 before settling back. The total has moved between 51.5 and 52.5 all week. Check the latest odds before locking in your bets on this NFC West matchup.

Opening Odds

Team	Spread	Total
Arizona Cardinals	+10.5 (-110)	Over 51.5 (-105)
Los Angeles Rams	-10.5 (-110)	Under 51.5 (-115)

Current Odds

Team	Spread	Total
Arizona Cardinals	+12.5 (-105)	Over 51.5 (-115)
Los Angeles Rams	-12.5 (-115)	Under 51.5 (-105)

Line Movement – Spread

Date	Arizona	L.A. Rams
10/13	+12.5 (-105)	-12.5 (-115)
10/13	+12.5 (-108)	-12.5 (-112)
10/13	+13.5 (-115)	-13.5 (-105)
10/12	+12.5 (-110)	-12.5 (-110)
10/12	+13.5 (-115)	-13.5 (-105)
10/11	+12.5 (-110)	-12.5 (-110)
10/06	+10.5 (-110)	-10.5 (-110)

The biggest move came on 10/11, when the Rams jumped two points from -10.5 to -12.5 with 98 percent of the money behind them. Los Angeles now holds 68 percent of the money and 51 percent of the tickets, and the price on Rams -12.5 has been bet up to -115.

Line Movement – Total

Date	Over	Under
10/13	51.5 (-115)	51.5 (-105)
10/13	52.5 (-110)	52.5 (-110)
10/13	52.5 (-105)	52.5 (-115)
10/12	52.5 (-110)	52.5 (-110)
10/12	51.5 (-115)	51.5 (-105)
10/11	52.5 (-105)	52.5 (-115)
10/11	52.5 (-110)	52.5 (-110)
10/06	51.5 (-105)	51.5 (-115)

The total has toggled between 51.5 and 52.5 and currently sits at its opening number. The under drew all of the early action on 10/11, but the over now holds 93 percent of the money and 71 percent of the tickets, with the over price juiced to -115.

Cardinals vs Rams Key Matchups and Handicap

Rams Own the Recent NFC West Series

Los Angeles has controlled this rivalry. Over the last three seasons, the Rams are 5-1 straight up and 4-2 against the spread against Arizona. Last year’s two meetings were not competitive, as Los Angeles won by 28 and 17 points. The scoring has also been reliable, with four of the last five meetings going over the total.

Cardinals Collapsing After a Week 1 Win

Arizona opened the season with a win over the Chargers, but it has been all downhill since. The Cardinals have lost four straight games by an average of 16.5 points while allowing an average of 37.0 points per game during the skid. The defense had no answers for the Lions last week, and the season is starting to look a lot like last year’s.

At full strength, Arizona can be feisty against anyone. The problem is depth. The Cardinals’ roster is so thin that once injuries and attrition begin to pile up, everything goes off the rails, and that is exactly what is happening now.

Los Angeles Looking to Rebound After Overtime Loss

The Rams should be in a feisty mood after falling at home to the Bills in overtime on Monday night. Los Angeles dominated much of the box score, finishing +2 in turnover differential with 454 total yards and 33 first downs, but two missed field goals proved to be the difference.

Sean McVay will have plenty to address in practice. The Rams’ defense allowed 7.6 yards per play to Buffalo, and the team committed 11 penalties. Expect a sharper, more disciplined effort against a struggling division rival.

Arizona’s Pass Defense Ranks Near the Bottom

The Rams’ offense should be able to get whatever it wants in this matchup. Arizona’s defense ranks 31st in EPA per drop-back allowed and 25th in passing success rate allowed. After moving the ball at will against Buffalo, Los Angeles faces a much softer defense this week.

ARI and LAR Games Trending Over

Both teams have been involved in high-scoring games lately. Arizona’s last three games have gone over the total, and so have the Rams’ last three games. With the Rams capable of scoring heavily on their own, this total has a clear path toward the mid-50s.

Arizona can also contribute points late. Mike LaFleur is trying to build a winning culture, and he kept his starters in while pushing to score down 45-14 in the final minutes against Detroit last week. Any Cardinals points in garbage time would be a bonus for over bettors.

ARI vs LAR Betting Trends

The Rams are 5-1 straight up and 4-2 against the spread against Arizona over the last three seasons.
Los Angeles won last season’s two meetings by 28 and 17 points.
Four of the last five meetings between Arizona and Los Angeles have gone over the total.
Arizona has lost four straight games by an average of 16.5 points.
Arizona has allowed an average of 37.0 points per game during its four-game losing streak.
Arizona’s last three games have gone over the total.
The Rams’ last three games have gone over the total.
The spread has moved from Rams -10.5 to -12.5, with Los Angeles drawing 68 percent of the money.

ARI vs LAR Key Injuries and Notes

Arizona’s thin roster has struggled as injuries and attrition have mounted during its losing streak.
Arizona’s defense ranks 31st in EPA per drop-back allowed and 25th in passing success rate allowed.
Mike LaFleur kept Arizona’s starters in late while trailing 45-14 to Detroit last week.
The Rams generated 454 total yards and 33 first downs in last week’s overtime loss to Buffalo.
The Rams missed two field goals and committed 11 penalties against Buffalo.
The Rams’ defense allowed 7.6 yards per play to Buffalo.
Check final injury reports before kickoff for updates on both rosters.

Cardinals vs Rams ATS and Total Picks

Rams -12.5 Spread Pick

Laying nearly two touchdowns in a division game requires confidence, and this matchup provides it. The Rams moved the ball with ease last week and only lost because of missed kicks and penalties, both of which are fixable. Arizona is losing by more than 16 points per game during its skid and has one of the worst pass defenses in the league. Los Angeles has won last year’s two meetings by an average of 22.5 points, and the market has steadily backed the Rams all week.

Pick: Los Angeles Rams -12.5 (-115)

Cardinals vs Rams Over Pick

Everything points toward a high-scoring game. Both teams have gone over in each of their last three games, four of the last five meetings have gone over and Arizona is allowing 37 points per game during its losing streak. The Rams should score heavily against a pass defense ranked 31st in EPA per drop-back, and Arizona’s willingness to keep pushing for points late only adds to the over’s chances. This game has a realistic path to the mid-50s.

Pick: Over 51.5 (-115)

Arizona vs Los Angeles Best Bets

Best Bet: Over 51.5 (-115)
Spread: Los Angeles Rams -12.5 (-115)

The over is the top play. Both teams are on three-game over runs, Arizona’s defense is giving up points in bunches and the Rams’ offense just produced 454 yards. Los Angeles on the spread is also a strong play given the series history and Arizona’s lopsided losses. The Rams on the moneyline is the safest way to back the clearly superior team.

Final Score Prediction for Cardinals vs Rams

The Rams carry over the offensive production they showed against Buffalo, but with cleaner execution and fewer penalties. Arizona’s pass defense cannot keep up, and Los Angeles builds a comfortable lead by halftime. The Cardinals continue pushing for points late, adding to the total, but the result is never in doubt.