Best Home Run Prop Bets Today – HR Prop Picks For Friday, August 22

The 2025 MLB season is here, and who doesn’t love home run prop bets? Tons of home runs have already been hit this season and we’re ready to pick more winners in 2025! Free home run prop picks each day come at you compliments of WagerTalk.
Let’s see if we can beat the books with home run prop bets on Friday! You can find free MLB picks every day at WagerTalk! Here are the best home run prop bets to make for Friday, August 22!
Best Home Run Prop Bets – MLB Free HR Props Picks
Brandon Lowe (TB) +320
Miles Mikolas takes the mound for the Cardinals tonight in Tampa Bay as the Rays look to bounce back from a 7-4 series opening loss last night.
Although the St. Louis starter hasn’t allowed a home run in his last two starts, both of those came at home where he’s a much better pitcher.
On the season Mikolas has allowed 15 of his 21 home runs on the road while posting a 6.47 ERA compared to a 3.70 ERA at home.
We’re going with Brandon Lowe to hit his home run prop tonight slugging .523 across the last 15 days. Sure, Lowe has been a better hitter on the road this season, but he has hit half of his home runs at home and is batting .290 and slugging .542 against righties this season.
Mikolas has allowed 13 of his 21 home runs to left handed hitters and in his last two road starts Mikolas has allowed five home runs in just seven innings to the Dodgers and Diamondbacks.
Take Lowe to hit his home run prop tonight with odds listed at +320. Other Rays batters to look at for a home run includes Junior Caminero (+285) and Josh Lowe (+600).
MLB HR Props Best Bet of the Day #2: Freddie Freeman (LAD) +390
Freddie Freeman has hit a home run in back-to-back games this season twice already and we think it happens for a third time after hitting a home run in yesterday’s series finale at Colorado.
The Dodgers now head to San Diego to take on the Padres sending out veteran Yu Darvish to the mound. Freeman has been on fire this month now batting .333 with a .611 slugging percentage in August so far and all-time against Darvish is 12-45 with four home runs and three doubles.
Darvish’s last start actually came against the Dodgers on the road in which he gave up a home run to Freeman, going only four innings while giving up four earned runs.
The San Diego starter has given up four home runs combined across his last three starts (14 IP) while allowing a .473 slugging percentage to left handed batters compared to a .403 slugging percentage to right handed hitters.
Freeman is batting .346 with a .692 slugging percentage across his last seven days so let’s take him to keep his hot streak going with odds on his home run prop listed at +390.
Other Dodgers to look at for a home run prop includes Shohei Ohtani (+200) and Teoscar Hernandez (+400).
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