49ers vs Seahawks Picks, Predictions and Odds Week 5 October 11, 2026

The last time San Francisco visited Lumen Field, Rashid Shaheed returned the opening kickoff 95 yards for a touchdown, Seattle led 17-0 before the end of the first quarter, and the Seahawks rolled to a 41-6 Division Round win on their way to a Super Bowl title. A lot has changed since January. Kenneth Walker III now runs for the Chiefs, Seattle’s backfield is so thin that Joe Mixon was pulled off the scrap heap, and Sam Darnold’s turnover problems are resurfacing.

Meanwhile, the unbeaten 49ers have already beaten the Rams and Broncos by double digits behind an MVP-level Brock Purdy. This 49ers vs Seahawks prediction examines whether San Francisco can extend its regular season success in Seattle. Before you finalize your NFL picks, here is the full breakdown of odds, line movement, matchups, and best bets.

Quick Picks and Prediction

Moneyline Pick: San Francisco 49ers
Spread Pick: San Francisco +3 (-110)
Total Pick: Under 45.5 (-105)
Projected Final Score: 49ers 24, Seahawks 17

Odds and Line Movement for San Francisco vs Seattle

Seattle has been favored all week, with the spread bouncing between 2.5 and 3. The Seahawks drew 100 percent of the money early on October 4, but that support has cooled to 61 percent, while San Francisco now holds 56 percent of the tickets. The line currently sits at 3 with even juice on both sides. The total has dropped from 47.5 to 45.5, with the money split close to even but leaning Under. Check the live odds before kickoff, since getting the full field goal with San Francisco matters in a game this close.

Opening Odds

Team	Spread	Total
San Francisco 49ers	+3 (-118)	Over 47.5 (-110)
Seattle Seahawks	-3 (-102)	Under 47.5 (-110)

Current Odds

Team	Spread	Total
San Francisco 49ers	+3 (-110)	Over 45.5 (-115)
Seattle Seahawks	-3 (-110)	Under 45.5 (-105)

Line Movement – Spread

Date	San Francisco	Seattle
10/08	+3 (-110)	-3 (-110)
10/08	+3 (-112)	-3 (-108)
10/07	+2.5 (+102)	-2.5 (-122)
10/06	+2.5 (+100)	-2.5 (-120)
10/06	+3 (-120)	-3 (+100)
10/05	+2.5 (+100)	-2.5 (-120)
10/04	+3 (-120)	-3 (+100)
10/04	+3 (-118)	-3 (-102)
10/04	+3 (-115)	-3 (-105)
10/04	+3 (-118)	-3 (-102)

Line Movement – Total

Date	Over	Under
10/07	45.5 (-115)	45.5 (-105)
10/07	45.5 (-110)	45.5 (-110)
10/06	46.5 (-115)	46.5 (-105)
10/06	47.5 (+100)	47.5 (-120)
10/05	47.5 (-105)	47.5 (-115)
10/04	46.5 (-110)	46.5 (-110)
09/29	47.5 (-110)	47.5 (-110)

49ers vs Seahawks Key Matchups and Handicap

Last January’s lopsided playoff result looms over this matchup, but the circumstances are very different now. San Francisco is healthier at the most important positions and playing confident football, while Seattle has lost key pieces in its backfield and has looked sloppy in recent weeks.

A Rematch of Last January’s Rout

San Francisco entered last season’s NFC Divisional Round at Lumen Field badly banged up and fell behind immediately when Shaheed returned the opening kickoff 95 yards for a touchdown. Seattle built a 17-0 lead before the end of the first quarter and cruised to a 41-6 win. Walker scored three touchdowns and ran for 116 yards in that game before going on to win Super Bowl MVP.

Seahawks Lack Last Season’s Menace

Seattle does not have the same intimidating look this season, at least not yet. Walker is now running roughshod for the Chiefs, and with Zach Charbonnet and Notre Dame rookie Jadarian Price on the injured list, general manager John Schneider signed Joe Mixon. That is a desperate-looking roll of the dice, considering Mixon has not played since 2024. The Seahawks also committed 14 penalties last week, including seven 15-yard infractions, in a struggle against the winless Chargers.

Sam Darnold’s Old Ghosts Reappear

Darnold has not played at the same level as his counterpart. He already missed early action with a glute injury and has thrown a combined three interceptions over the last two weeks against the Commanders and Chargers. Turnovers against a 49ers team playing with this much confidence could be costly.

49ers Own Recent Trips to Seattle

San Francisco has fared well at Seattle in the regular season, winning four straight there, including in the opening week last season. The 49ers also showed they can win a grinder last week against Denver, holding the Broncos to only 4.6 yards per play. Already unbeaten, they have beaten the Super Bowl favorite Rams and last year’s AFC finalist Broncos by double digits.

Niners Passing Game Thriving Behind Brock Purdy

Purdy is playing at an MVP-like level with 1,007 passing yards, 11 touchdowns and just one interception. Injuries at wide receiver have not slowed him because he still has his safety blanket in tight end George Kittle, who has three touchdown catches over the last two weeks, including a 56-yard score that sealed the win over Denver. Deebo Samuel, back with the team as a free agent, has scored in three of four games, and veteran addition Mike Evans has played through nagging injuries and led San Francisco with 78 receiving yards against Vance Joseph’s sticky Denver defense.

Betting Trends: SF vs SEA

Seattle beat San Francisco 41-6 in last season’s NFC Divisional Round.
San Francisco has won four straight regular season games at Seattle.
San Francisco is unbeaten and has double-digit wins over the Rams and Broncos.
San Francisco held Denver to 4.6 yards per play last week.
Seattle committed 14 penalties, including seven 15-yard penalties, against the Chargers.
Seattle has held between -2.5 and -3 all week.
Seattle drew 100 percent of the spread money early but now holds 61 percent, while San Francisco has 56 percent of the tickets.
The total dropped from 47.5 to 45.5.
The Under holds 52 percent of the money, while the Over has 64 percent of the tickets.

Key Injuries and Notes: SF vs SEA

San Francisco 49ers:

The 49ers are dealing with a cluster of injuries at wide receiver.
Mike Evans has played through nagging injuries.
Brock Purdy has 1,007 passing yards, 11 touchdowns and one interception.

Seattle Seahawks:

Zach Charbonnet (RB) – Injured list
Jadarian Price (RB) – Injured list
Joe Mixon was signed after not playing since 2024.
Sam Darnold missed early action this season with a glute injury and has thrown three interceptions over the last two games.

ATS and Total Picks

Spread Pick: San Francisco +3 (-110)

The 49ers are unbeaten, playing excellent defense and getting MVP-level production from Purdy. Seattle’s backfield is depleted, Darnold is turning the ball over, and the Seahawks were sloppy against a winless team last week. San Francisco has also won four straight regular season games in Seattle. Getting a full field goal with the better team right now is a strong spot.

Total Pick: Under 45.5 (-105)

The total has fallen two points from the open, and both defenses have reasons for confidence. San Francisco held Denver to 4.6 yards per play, and Seattle’s running game is significantly weakened without Walker, Charbonnet and Price. The 49ers proved they can win a grinder, and a methodical game plan from both sides points to the Under.

49ers vs Seahawks Best Bets

Best Bet: San Francisco +3 (-110)
Moneyline Play: San Francisco 49ers
Total Play: Under 45.5 (-105)

San Francisco is the better team at the moment and has a strong recent history in Seattle. Take the 49ers with the points or on the moneyline, and pair them with the Under, as Seattle’s depleted backfield and San Francisco’s stout defense point to a lower-scoring game.

Final Score Prediction for San Francisco vs Seattle

Purdy leans on Kittle and Samuel to keep the offense moving, while the 49ers’ defense limits a Seattle running game missing its top options. Darnold makes another costly mistake, and San Francisco stays unbeaten with a fifth straight regular season win in Seattle.