| After beating the Packers last Thursday, the Falcons became the first NFL team to win back-to-back road games in primetime by 20+ points. |
| Prior to last January's Division Round loss at Seattle, the 49ers had won-and-covered four-straight regular season games at Lumen Field. San Francisco has also covered six of its last seven games away from Santa Clara (the lone loss being that 41-6 playoff defeat vs the Seahawks). |
| The Lions have now landed "over" in their first four games this season. That is part of a larger 11-3 run to the over since midway through the 2025 campaign. Meanwhile, the Cardinals look to snap an eight-game straight-up losing streak in Glendale and the Cardinals have failed to cover the number in each of their last five home games. |
| The Broncos have had little success at So Fi Stadium since it opened in 2020, losing outright in six of seven visits vs. the Chargers (six times) and the Rams (once). The Chargers, however, are working on a seven-game losing streak both straight-up and against the spread since late last season (though most received a push in last Sunday's 30-23 loss at Seattle). |
| While neither team is known for an explosive offense, the last three meetings between the Browns and Jets have gone over the total with those three contests seeing an average of 55.0 points per game. |
| Las Vegas has won-and-covered each of the last three meetings, including a 20-13 upset win in Foxboro in last year's season opener. The Raiders are 4-0 against the spread this season, covering the closing number in those contests by an average of 10.5 points per game. |
| New Orleans is 0-4 against the spread in the first halves this season, getting out-scored by a combined margin of 61-26. |
| Since the midway point of the 2024 season, the Steelers have gone 13-5 against the spread at home including a pair of point spread covers against the Falcons and Bengals to kick off the year. |
| The last four editions of this NFC East rivalry played at Northwest Stadium in the Washington suburbs have seen an average of 37.0 points per game. |
| If the opening point spreads hold true and Chicago closes as a road favorite in Green Bay, it will be the first time the Bears have been favored at Lambeau since Rex Grossman was the starting QB in 2006. |
| This will be the 14th game played at London's Tottenham Hotspur Stadium since 2019, including last week’s clash between the Colts and Commanders. The venue has produced some low-scoring results in recent years as the last seven games played at Hotspur Stadium have seen an average of 40.4 points per game. |
| Dating back to last Thanksgiving, the Cowboys' last ten games have all gone over the total. There were some +3's available at various points, but the consensus closing number was +2.5 for Tampa Bay last week against the Packers. Following that three-point loss at home to Green Bay, the Bucs have now failed to cover the spread in 13-straight games. |
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