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<\/a><\/figure>\n\n\n\n\n\nKey Matchups and Handicap: Cardinals vs Seahawks<\/h2>\n\n\n\n\n\n
This NFC West matchup has been completely one-sided in recent years, but both teams enter with major questions. Seattle is dealing with a quarterback crisis and a three-game slide in form, while Arizona is riding an emotional comeback win with a new starting quarterback and a growing injury list. The biggest difference this week is preparation time, and that should favor Seattle's defense.<\/p>\n\n\n\n\n\n
Seahawks Own This Rivalry<\/h3>\n\n\n\n\n\n
Seattle has gone 10-0 straight-up and 9-1 against the spread over the last 10 meetings, including a 31-7 road win in Arizona in Week 2. The Seahawks have won each of their last four home games against the Cardinals by double digits. However, Seattle is just 1-3 straight-up and ATS over its last four games after Monday night's home loss to the Bears. The 34 points allowed were the most surrendered by the Seahawks' defense in regulation since Week 5 of last season.<\/p>\n\n\n\n\n\n
Seattle Quarterback Crisis<\/h3>\n\n\n\n\n\n
Seattle quarterback Sam Darnold will miss this game, and potentially a few more, with an injured quad. Backup Drew Lock has seen significant minutes in two games this season, but he is also dealing with an elbow injury that has limited him for the past few weeks. If Lock cannot go, former Alabama quarterback Jalen Milroe, who has yet to throw a pass in his NFL career, would start.<\/p>\n\n\n\n\n\n
Cardinals Ride the Minshew Spark<\/h3>\n\n\n\n\n\n
Arizona earned a stunning come-from-behind win over Dallas last week after first-year head coach Mike LaFleur switched from Jacoby Brissett to Gardner Minshew II at halftime. In his first appearance of the season, Minshew went 17-of-23 for 188 yards and three touchdowns in just half a game. <\/p>\n\n\n\n\n\n
Since 2000, the Cardinals had been 1-147-1 when trailing by 14 or more points in the fourth quarter, before pulling off that late-game magic. Still, there is a big difference between riding the adrenaline of a surprise mid-game change and facing a defense that has had a full week to prepare for Minshew. Arizona's offense also did not find the end zone for the first 44 minutes against Dallas.<\/p>\n\n\n\n\n\n
Arizona Riddled With Injuries<\/h3>\n\n\n\n\n\n
LaFleur is doing an impressive job in his debut season, especially with Arizona's roster becoming riddled with injuries. Rookie running back Jeremiyah Love suffered another ankle injury against Dallas, fellow running back Bam Knight needs to clear concussion protocol, and wide receiver Kendrick Bourne suffered an ankle injury that could end his season. Those losses leave the Cardinals' offense thin heading into a hostile road environment.<\/p>\n\n\n\n\n\n
ARI vs SEA Betting Trends<\/h2>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n<\/ul>\n\n\n\n\n\nARI vs SEA Key Injuries and Notes<\/h2>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n<\/ul>\n\n\n\n\n\nCardinals vs Seahawks ATS and Total Picks<\/h2>\n\n\n\n\n\n
ATS Pick: Seahawks -8.5 (-108).<\/strong> The market has overreacted to Seattle's quarterback news, dropping the line four points from its peak. Seattle's defense should be far better prepared for Minshew than Dallas was, and Arizona's offense is missing multiple key skill players. The Seahawks have dominated this series, winning their last four home meetings by double digits.<\/p>\n\n\n\n\n\nMoneyline Pick: Seattle Seahawks.<\/strong> Even with a backup quarterback, Seattle has the healthier roster, the home field, and a defense with a full week to prepare.<\/p>\n\n\n\n\n\nTotal Pick: Under 39.5 (-108).<\/strong> Both offenses are compromised, with Seattle potentially starting a rookie who has never thrown an NFL pass and Arizona missing key running backs and a top receiver. Expect a conservative, field-position game dominated by defense.<\/p>\n\n\n\n\n\nCardinals vs Seahawks Best Bets<\/h2>\n\n\n\n\n\n\n\n\n\n\n\n<\/ul>\n\n\n\n\n\nFinal Score Prediction for Cardinals vs Seahawks<\/h2>\n\n\n\n\n\n
Seattle's offense will be limited without Darnold, but its defense should bounce back and frustrate a banged-up Arizona attack. Expect the Seahawks to extend their dominance in this series with a low-scoring home win that covers the spread and stays under the total.<\/p>\n\n\n\n\n\n
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